The Science of SMHeartCard

SMHeartCard solves a big problem: many Canadians are at risk of heart attack but don't have a convenient way to carry Nitroglycerin and ASA. Studies show that the sooner treatment starts for a heart attack, the more likely you are to survive, because minutes matter (Reference #1).  In a study of 38 consecutive Canadian patients with known coronary artery disease prescribed standard Nitroglycerin and ASA, only 20% of patients, and only 11% of men, carried their Nitroglycerin with them; none carried ASA (Reference #2). 

Nitroglycerin is a fragile chemical that reacts with air and standard plastics. SMHeartCard uses a new, patent-pending technology to seal Nitroglycerin pills in a chemically inert case away from oxygen, moisture, and light that can break down Nitroglycerin. SMHeartCard seals ASA pills from air and moisture (Reference #3).

SMHeartCard performance was validated at the University of Alberta Faculty of Pharmacy and Pharmaceutical Sciences in the laboratory of Professor Neal Davies. These comprehensive studies show that SMHeartCard effectively keeps Nitroglycerin and ASA tablets ready for when you need them (Reference #4)A wide range of storage conditions have been tested, including validation across a range of temperatures ranging from 4 degrees Celsius to 60 degrees Celsius. SMHeartCard performs as well at body temperature as when pills are stored in the manufacturers packaging unopened, at room temperature, even when stored for six months.

At the time of a heart attack, ASA works to stop platelets from sticking to the side of a coronary artery and making blood clots worse. ASA has been shown to markedly improve the chances of surviving a heart attack. Nitroglycerin works to open up the coronary arteries and reduce the workload of the heart; this reduces its need for oxygen. 

Recent studies show that daily aspirin to prevent heart attacks is ineffective in those 70 years and older (Reference #5): it is better to use the SMHeartCard approach of "ready and available when needed".


1. Acute ischemic syndromes. Early response. Cardiol Clin, Vanlandingham 2002.

2. Poor Compliance With Carrying Nitroglycerin and Aspirin in Patients With Coronary Artery Disease. Canadian Journal of Cardiology, Horseman et. al. 2018. 

3. Improving compliance and access to nitroglycerin and aspirin in people with coronary artery disease: development and validation of the SMHeartCard system. Canadian Cardiovascular Congress, Le et. al. 2018. 

4. Validation of the SMHeartCard nitroglycerin table storage system. Le T, Davies N, manuscript in preparation. 

5. Effect of Aspirin on Disability-free Survival in the Healthy Elderly New England J Med, McNeil J et. al.  2018.